2013 · Annals of Internal Medicine 158(11):781–790
Sunscreen and prevention of skin aging: a randomized trial
Hughes MCB, Williams GM, Baker P, Green AC
- Study
- Randomised trial, 903 adults under 55, 4.5 years (Nambour, Australia)
- Finding
- People who applied sunscreen daily showed no measurable increase in skin ageing after 4.5 years. Compared with the group that used it only as needed, skin ageing was about 24 % lower. Beta-carotene supplements had no overall effect.
- What it means for you
- Daily sunscreen is the best-supported step against visible skin ageing. That's why it's in every Skinpaired routine.
Source on PubMed ›
2005 · Dermatologic Surgery 31(7 Pt 2):860–865
Niacinamide: A B vitamin that improves aging facial skin appearance
Bissett DL, Oblong JE, Berge CA
- Study
- Double-blind split-face study, 50 women, 5 % niacinamide vs. base cream, 12 weeks
- Finding
- The niacinamide side showed fewer fine lines, fewer dark spots, less red blotchiness and less sallowness. The cream was well tolerated.
- What it means for you
- Niacinamide is a well-tolerated all-rounder. Skinpaired often uses it instead of stronger actives for reactive skin.
Source on PubMed ›
2006 · Journal of Cosmetic and Laser Therapy 8(2):96–101
The effect of 2% niacinamide on facial sebum production
Draelos ZD, Matsubara A, Smiles K
- Study
- Two controlled studies: 100 participants in Japan (4 weeks) and 30 in the USA (split-face, 6 weeks), 2 % niacinamide
- Finding
- In the Japanese group, sebum production dropped measurably; in the US group, the amount of sebum on the skin surface dropped.
- What it means for you
- For shine and combination skin, Skinpaired picks niacinamide as the first active.
Source on PubMed ›
2007 · Archives of Dermatology 143(5):606–612
Improvement of naturally aged skin with vitamin A (retinol)
Kafi R, Kwak HSR, Schumacher WE et al.
- Study
- Randomised double-blind study, 36 older adults, 0.4 % retinol on the upper arm vs. base lotion, 24 weeks
- Finding
- Fine wrinkles decreased clearly on the retinol side. Skin samples showed more collagen precursors and water-binding substances.
- What it means for you
- Retinoids are among the best-studied actives for fine lines. They need a step-up phase, so Skinpaired increases them gradually.
Source on PubMed ›
1998 · Journal of the American Academy of Dermatology 39(6):960–965
Profilometric evaluation of photodamage after topical retinaldehyde and retinoic acid treatment
Creidi P, Vienne MP, Ochonisky S et al.
- Study
- Controlled comparison, 125 evaluated: 0.05 % retinal, 0.05 % retinoic acid or base cream, 44 weeks
- Finding
- Retinal and retinoic acid both measurably smoothed lines and roughness. Retinal was tolerated much better than retinoic acid.
- What it means for you
- Retinal is an effective and usually gentler option. Skinpaired recommends it at a low strength to start.
Source on PubMed ›
2015 · Clinical, Cosmetic and Investigational Dermatology 8:455–461
Salicylic acid as a peeling agent: a comprehensive review
Arif T
- Study
- Review of how salicylic acid works and how safe it is
- Finding
- Salicylic acid is oil-soluble, so it reaches into oily pores. It loosens the bonds between dead skin cells and keeps pores clear.
- What it means for you
- For blemishes and blackheads, Skinpaired uses salicylic acid in the evening, but never on the same evening as a retinoid.
Source on PubMed ›
2013 · Indian Dermatology Online Journal 4(2):143–146
Vitamin C in dermatology
Telang PS
- Study
- Review of vitamin C in skincare
- Finding
- Vitamin C acts as an antioxidant and can buffer UV-related stress in the skin. Pure ascorbic acid is unstable, so more stable forms and good packaging are being researched.
- What it means for you
- In Skinpaired, vitamin C goes on in the morning under sunscreen, where it complements it. Replace serums that have turned brownish.
Source on PubMed ›
2011 · Journal of Drugs in Dermatology 10(9):990–1000
Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment
Pavicic T, Gauglitz GG, Lersch P et al.
- Study
- Randomised study, 0.1 % hyaluronic acid in five molecular sizes around the eyes, 60 days
- Finding
- All forms improved hydration and elasticity. Smaller molecules also reduced the depth of fine lines.
- What it means for you
- Hyaluronic acid is a gentle hydration step that fits with every active. Skinpaired uses it in the “Hydrate” step.
Source on PubMed ›
2017 · Journal of Dermatological Treatment 28(8):766–773
Topical use of dexpanthenol: a 70th anniversary article
Proksch E, de Bony R, Trapp S, Boudon S
- Study
- Review with a systematic literature search on panthenol on the skin
- Finding
- Several controlled studies show that panthenol hydrates the skin and strengthens the skin barrier.
- What it means for you
- Panthenol is a plus in creams, especially for irritated skin and after shaving.
Source on PubMed ›
2016 · British Journal of Dermatology 174(2):319–329
Prevalence of contact allergy in the general population in different European regions
Diepgen TL, Ofenloch RF, Bruze M et al.
- Study
- Population study in five European countries, 3,119 people patch-tested
- Finding
- Just over a quarter of those tested reacted to at least one of the tested substances. Fragrance mixes were among the more common triggers at almost 2 %.
- What it means for you
- If your skin reacts easily, fragrance-free care is the safer choice. Skinpaired can filter for fragrance-free products only.
Source on PubMed ›
Legal framework
Commission Regulation (EU) 2024/996 of 3 April 2024
Limits retinol, retinyl acetate and retinyl palmitate in cosmetics to 0.3 % retinol equivalent in face products and 0.05 % in body lotion. Products already on sale have transition periods.
Regulation on EUR-Lex ›
Cosmetic information, not medical advice. Studies are summarised in our own words; the original source is authoritative.
